Computer Assisted Kinetic Evaluation

Computer Assisted Kinetic Evaluation (CAKE) is a simple to use tool which implements both the FOCUS Kinetics and the NAFTA guidance to generate degradation kinetics.

CAKE Usage and Distribution

CAKE 3.7 is a tool to assist with the production of kinetic fits in accordance with FOCUS-Kinetics guidance (FOCUS,2006 and FOCUS, 2014), NAFTA guidance (NAFTA, 2015) and some parts of the ICAMA guidance. The current version with a build date of 24 March 2023 (made available to download from 8 June 2023) is developed by Hybrid Intelligence, part of Capgemini Engineering (formerly known as Tessella) and is sponsored by Syngenta Ltd. Scientific and technical advice on the kinetic fitting is provided by Ian Hardy and Simon Ford from Battelle UK Ltd.

CAKE is and will be distributed on a free to use basis subject to the conditions stated in the Software Licence. You must agree to these terms before downloading, installing, distributing or using CAKE.

Enquiries

Please direct all enquiries on CAKE, including requests related to the availability of previous versions, to: cake.support@syngenta.com

Installing CAKE

To install CAKE 3.7, download the appropriate installer for your operating system and follow the steps of the installer.

This version of CAKE bundles R 4.1.1 along with all the needed libraries. By accepting the license of CAKE, you are also accepting the license of R.

References

FOCUS (2006). Guidance document on estimating persistence and degradation kinetics from environmental fate studies on pesticides in EU registration. Report of the FOCUS Work Group on Degradation Kinetics, EC Document Reference Sanco/10058/2005, version 2.0, 434 pp.

FOCUS (2014). Generic guidance for Estimating Persistence and Degradation Kinetics from Environmental Fate Studies on Pesticides in EU Registration. Version 1.1. 440 pp.

NAFTA (2015). Guidance for Evaluating and Calculating Degradation Kinetics in Environmental Media. 23rd March 2015

ICAMA (2017). Guidance for evaluating and calculating degradation kinetics in environmental media for pesticide registration. Institute for the Control of Agrochemicals, Ministry of Agriculture of the People’s Republic of China. NY/T 3150-2017ICAMA citation?